Acetate Type Haemodialysis System
- Acetate is a normal metabolite in the human body.
- The metabolism of acetate generates bicarbonate and acetate therefore adds to the buffer gain during dialysis.
- The presence of 3–5 mmol/l acetate or more in dialysis fluid leads during dialysis to diffusive transfer of acetate into blood, generally resulting in a 5- to 10-fold increase in plasma acetate level during dialysis. The post dialysis acetate level varies greatly among patients, ranging from below 100 to above 500 μmol/l, primarily related to varying ability to metabolize acetate.
- bicarb type buffer dialysate is the more preferred solution due to problems in chronic HD patients with persistent metabolic acidosis.
The composition of SBPL’s acetate buffer is as follows:
For each 1000ml:
PART I : The acid concentrate (in liquid form) is composed of the following components in each 1000ml:
- NaCl : 204.75g
- KCl: 5.22g
- CaCl2: 7.72g
- MgCl2: 3.56g
- Sodium acetate: 181.00g
- H20: Q.S
Procedure for use:
To be diluted with 34 volumes of purified water and no separate Part II is provided for this.