Acetate Type Haemodialysis System

  • Acetate is a normal metabolite in the human body.
  • The metabolism of acetate generates bicarbonate and acetate therefore adds to the buffer gain during dialysis.
  • The presence of 3–5 mmol/l acetate or more in dialysis fluid leads during dialysis to diffusive transfer of acetate into blood, generally resulting in a 5- to 10-fold increase in plasma acetate level during dialysis. The post dialysis acetate level varies greatly among patients, ranging from below 100 to above 500 μmol/l, primarily related to varying ability to metabolize acetate.
  • bicarb type buffer dialysate is the more preferred solution due to problems in chronic HD patients with persistent metabolic acidosis.

The composition of SBPL’s acetate buffer is as follows:

For each 1000ml:

PART I : The acid concentrate (in liquid form) is composed of the following components in each 1000ml:

  • NaCl : 204.75g
  • KCl: 5.22g
  • CaCl2: 7.72g
  • MgCl2: 3.56g
  • Sodium acetate: 181.00g
  • H20: Q.S

Procedure for use:

To be diluted with 34 volumes of purified water and no separate Part II is provided for this.